Cancer Research: Coley's Toxins



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Coley Toxins is a form of immunotherapy using bacterial cultures that may improve the body’s immune system and prevent cancer. Studies going back as the 1700’s show that this treatment had reduced the malignancy of cancers. The active component in Coley’s Toxins is TNF alpha or Tumor necrosis factor alpha which was isolated in the 1970’s. TNF alpha is as a cytokine, a signaling molecule that alert cells to sites of inflammation, infection and trauma.

According to the British Journal of Medicine:

“A wide variety of evidence has pointed to a critical role of TNF-α in tumour proliferation, migration, invasion and angiogenesis. The function of TNF-α as a key regulator of the tumour microenvironment is well recognized. We will emphasize the contribution of TNF-α and the nuclear factor-κB pathway on tumour cell invasion and metastasis. Understanding the mechanisms underlying inflammation-mediated metastasis will reveal new therapeutic targets for cancer prevention and treatment.”

Wu, Y., and B P Zhou. “TNF-α/NF-κB/Snail Pathway in Cancer Cell Migration and Invasion.” Nature Publishing Group

Sources and Research:

Coley’s toxins, tumor necrosis factor and cancer research: a historical perspective.

TNF-α in Cancer Treatment: Molecular Insights, Antitumor Effects, and Clinical Utility


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